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  • 产品名称：anti-GRIN2Cantibody(GlutamateReceptor,Ionotropic,N-MethylD-Aspartate2c)(AA567-5

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简单介绍：
anti-GRIN2Cantibody(GlutamateReceptor,Ionotropic,N-MethylD-Aspartate2c)(AA567-595)
详情介绍：
Immunogen This GRIN2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 567-595 amino acids from the Central region of human GRIN2C.
Clone RB40514
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name GRIN2C (GRIN2C Antibody Abstract)
Background N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq].

Synonyms: GRIN2C, NMDAR2C, Glutamate [NMDA] receptor subunit epsilon-3, N-methyl D-aspartate receptor subtype 2C
NCBI Accession NP_000826
UniProt Q14957
Pathways Synaptic Membrane
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.32 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) (AA 567-595), (Center) antibody (ABIN1881390) GRIN2C Antibody (Center) (ABIN1881390) western blot analysis in mouse cerebellum tiss...
Product cited in: Need, Keefe, Ge, Grossman, Dickson, McEvoy, Goldstein: "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis." in: European journal of human genetics : EJHG, Vol. 17, Issue 7, pp. 946-57, 2009 (PubMed).

Krapivinsky, Krapivinsky, Manasian, Ivanov, Tyzio, Pellegrino, Ben-Ari, Clapham, Medina: "The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1." in: Neuron, Vol. 40, Issue 4, pp. 775-84, 2003 (PubMed).

Self, Mulholland, Nath, Harris, Prendergast: "The human immunodeficiency virus type-1 transcription factor Tat produces elevations in intracellular Ca2+ that require function of an N-methyl-D-aspartate receptor polyamine-sensitive site." in: Brain research, Vol. 995, Issue 1, pp. 39-45, 2003 (PubMed).