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  • 产品名称：anti-Crystallin,alphaA(CRYAA)(AA77-106),(Center)antibody

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  • 产品厂商：半导体
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简单介绍：
anti-Crystallin,alphaA(CRYAA)(AA77-106),(Center)antibody
详情介绍：
Immunogen This CRYAA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-106 amino acids from the Central region of human CRYAA.
Clone RB28544
Predicted Reactivity Cow (Bovine),Mouse (Murine),Pig (Porcine),Rat (Rattus),Rabbit
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name CRYAA (CRYAA Antibody Abstract)
Background Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families, beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits, the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq].

Synonyms: CRYAA, CRYA1, HSPB4, Alpha-crystallin A chain, Heat shock protein beta-4, Alpha-crystallin A chain, short form
NCBI Accession NP_000385
UniProt P02489
Pathways M Phase
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Crystallin, alpha A (CRYAA) (AA 77-106), (Center) antibody (ABIN1881229) CRYAA Antibody (Center) (ABIN1881229) western blot analysis in HepG2 cell line lysate...
Product cited in: Deng, Chen, Xie, Zhao, Gong, Liu, Zhang, Sun, Liu, Ma, Batra, Li: "The small heat shock protein alphaA-crystallin is expressed in pancreas and acts as a negative regulator of carcinogenesis." in: Biochimica et biophysica acta, Vol. 1802, Issue 7-8, pp. 621-31, 2010 (PubMed).

Li, Yang, Ma, Zhang, Zhang, Wang, Zhu: "Autosomal dominant congenital nuclear cataracts caused by a CRYAA gene mutation." in: Current eye research, Vol. 35, Issue 6, pp. 492-8, 2010 (PubMed).

Pang, Su, Feng, Tang, Gu, Zhang, Ma, Yan: "Effects of congenital cataract mutation R116H on alphaA-crystallin structure, function and stability." in: Biochimica et biophysica acta, Vol. 1804, Issue 4, pp. 948-56, 2010 (PubMed).

Bhagyalaxmi, Padma, Reddy, Reddy: "Association of G>A transition in exon-1 of alpha crystallin gene in age-related cataracts." in: Oman journal of ophthalmology, Vol. 3, Issue 1, pp. 7-12, 2010 (PubMed).