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Alternative Name
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GCK (GCK Antibody Abstract)
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Background
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Function
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Cellular Location
Cytoplasm. Nucleus. Note=Under low glucose concentrations, GCK associates with GKRP and the inactive complex is recruited to the hepatocyte nucleus
Tissue Location
Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver
Synonyms: Hexokinase D, Hexokinase type IV, HK IV, HK4, Glucokinase
Pathways: Glycolysis / Gluconeogenesis, Insulin signaling pathway, Type II diabetes mellitus, Galactose metabolism, Maturity onset diabetes of the young
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Molecular Weight
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52191 Da
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Gene ID
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2645
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UniProt
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P35557
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Research Area
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Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
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Pathways
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MAPK Signaling, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process
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