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  • 产品名称：SMAD,MothersAgainstDPPHomolog6(SMAD6)(C-Term)Peptide

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  • 产品厂商：半导体
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简单介绍：
SMAD,MothersAgainstDPPHomolog6(SMAD6)(C-Term)Peptide
详情介绍：
Blocked Antibody anti-SMAD6 antibody (SMAD, Mothers Against DPP Homolog 6) (C-Term) (ABIN2779803)
Sequence PDGVWAYNRG EHPIFVNSPT LDAPGGRALV VRKVPPGYSI KVFDFERSGL
Characteristics This is a synthetic peptide designed for use in combination with anti-Smad6 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Purification Purified
Background Smad6 binds to regulatory elements in target promoter regions. It may block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. It acts as a mediator of TGF-beta and BMP antiflammatory activity. It suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes.

Protein Size: 459
Molecular Weight 54 kDa
Gene ID 17130
UniProt O35182
Research Area Signaling, Transcription Factors
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Concentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handling Advice Avoid repeat freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.