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Purpose
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Reversible caspase-3, 6, 7, 8, 10 inhibitor
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Sequence
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Acetyl-Asp-Glu-Val-Asp-CHO
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Specificity
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Ac-DEVD-CHO is a reversible inhibitor of caspase-3 (IC50=200 mM). It will also inhibit caspase-6, caspase-7, caspase-8 and caspase- 10.
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Characteristics
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Caspase-3/CPP32 is a member of the cysteine proteases family involved in apoptosis induction. All apoptotic pathways studied to date involve proteolytic activation of Caspase-3/CPP32 as a central event in the progression of cell death. Although the death-inducing consequences of Caspase-3/CPP32 activation have not been conclusively established, several crucial substrates for the protease have been indentified in vitro, including DNA-dependent protein kinase, Poly(ADP-ribose) Polymerase (PARP), Replication factor C, and Gelsolin. These substrates are involved in the later stages of apoptosis, strongly suggesting that Caspase-3/CPP32 has a key role in promoting the final processes leading to cell death.
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Purity
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> 98 % by HPLC.
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Formula
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C20H30N4O11
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Solubility
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Soluble in both DMSO and water.
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