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  • 产品名称：anti-GSK3alphaantibody(GlycogenSynthaseKinase3alpha)

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简单介绍：
anti-GSK3alphaantibody(GlycogenSynthaseKinase3alpha)
详情介绍：
Immunogen Synthetic peptide of human GSK3A
Isotype IgG
Purification Antigen affinity purification
Alternative Name GSK3A (GSK3a Antibody Abstract)
Background This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth.
Pathways PI3K-Akt Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid freeze / thaw cycles.
Storage -20 °C/-80 °C
Storage Comment Store at -20°C (regular) and -80°C (long term).
Supplier Images
Immunohistochemistry (IHC) image for anti-Glycogen Synthase Kinase 3 alpha (GSK3a) antibody (ABIN2431485) Immunohistochemistry of Human renal cancer using GSK3A Polyclonal Antibody at dilutio...