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Background
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MACC1 is a key regulator of the hepatocyte growth factor (HGF, MIM 142409)-HGF receptor (HGFR, or MET, MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival Synonyms: 7A5, SH3BP4L
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