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  • 产品名称：anti-DFFAantibody(DNAFragmentationFactor,45kDa,alphaPolypeptide)

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  • 产品厂商：国内供应2
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简单介绍：
anti-DFFAantibody(DNAFragmentationFactor,45kDa,alphaPolypeptide)
详情介绍：
Immunogen Recombinant protein of human DFFA
Isotype IgG
Purification Antigen affinity purification
Alternative Name DFFA (DFFA Antibody Abstract)
Background Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Synonyms: DFF1, ICAD, DFF-45
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid freeze / thaw cycles.
Storage -20 °C/-80 °C
Storage Comment Store at -20°C (regular) and -80°C (long term).
Supplier Images
Immunohistochemistry (IHC) image for anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) antibody (ABIN2428255) Immunohistochemistry of Human thyroid cancer using DFFA Polyclonal Antibody at diluti...