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  • 产品名称：D64131

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  • 产品厂商：TargetMol
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简单介绍：
D64131
详情介绍：
Purpose D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM. The polymerization of bovine brain tubulin as well as binding of [3H] colchicine to biotinylated αβ-tubulin was dose-dependently inhibited by D-64131. Many cancer cells display abnormal microtubule structures, such as fragmented mitotic spindles or multiple spindle poles after treatment with D-64131. Nuclear blebbing and abnormal nuclear structures typical for apoptotic cells are detectable in many cells treated with D-64131. In nude mice, D-64131 proved to be well tolerated and highly active against the human amelanoic melanoma MEXF 989 tumor xenograft. D-64131 treatment resulted in significant tumor growth inhibition during treatment.
Characteristics Target: Microtubule Associated inhibitor
Receptor: tubulin polymerization
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 98 %
Formula C16H13NO2
Solubility Soluble in DMSO
Molecular Weight 251.28 g/mol
CAS-No 74588-78-6
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months