anti-Abeta43(AA38-43)antibody 抗体网

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产品名称：anti-Abeta43(AA38-43)antibody
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产品厂商：SYSY
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简单介绍：

anti-Abeta43(AA38-43)antibody

详情介绍：

Product details
Product details
Immunogen	Synthetic peptide corresponding to aa 38-43 of Abeta peptide 43 coupled to key-hole limpet hemocyanin via an added N-terminal cysteine residue.
Specificity	Specific for Abeta 43
Purification	Affinity purified with the immunogen. Rabbit serum albumin was added for stabilization.

Target details
Target details
Background	Synonyms: Beta-App, ABPP

Application Details
Application Details
Application Notes	WB: 1 : 1000 (ECL detection) IP: not tested yet ICC: not tested yet IHC-P: 1 : 100 ELISA: not tested yet
Comment	WB: Detects purified Abeta 43. Complex samples like brain extracts still have to be tested. Nitrocellulose membrane is recommended for blotting.
Restrictions	For Research Use only

Handling
Handling
Format	Lyophilized
Reconstitution	For reconstitution add 50 μL H2O to get a 1mg/ml solution of antibody in PBS. Then aliquot and store at -20 °C until use.
Buffer	PBS
Handling Advice	Affinity purified antibodies are less robust than antisera, since protease inhibitors are also removed during purification. Hence, storage at 4?°C for prolonged periods (i.e. several weeks), is not recommended.
Storage	-20 °C
Storage Comment	Unlabeled lyophilized antibodies are stable in this form without loss of quality at ambient temperatures for several weeks or even months. They can be stored at 4°C for several years. Lyophilized antibodies must not be stored in the freezer, they may be destroyed!

Images
Images
Supplier Images	ECL detection of different synthetic Abeta species (100 ng) with anti-Abeta 43 (dilut... anti-Abeta 43 (AA 38-43) antibody (Image 2) Indirect immunostaining of a PFA fixed paraffin embedded cortex section from a sporad... Images for product: anti-Abeta 43 (AA 38-43) antibody ECL detection of different synthetic Abeta species (100 ng) with anti-Abeta 43 (dilution 1 : 1000) and a commercially available monoclonal anti-Abeta antibody (4G8, Covance, dilution: 1 : 3000). anti-Abeta 43 (AA 38-43) antibody (Image 2) Indirect immunostaining of a PFA fixed paraffin embedded cortex section from a sporadic Alzheimer's disease patient (dilution 1 : 100; red). Immunoreactivity in amyloid plaques was revealed using diaminobenzidine as chromagen. Nuclei were counterstained with haematoxylin (blue).

References
References
Product cited in:	Reinert, Martens, Huettenrauch, Kolbow, Lannfelt, Ingelsson, Paetau, Verkkoniemi-Ahola, Bayer, Wirths: "Aβ38 in the brains of patients with sporadic and familial Alzheimer's disease and transgenic mouse models." in: Journal of Alzheimer's disease : JAD, Vol. 39, Issue 4, pp. 871-81, 2014 (PubMed). Bouter, Dietrich, Wittnam, Rezaei-Ghaleh, Pillot, Papot-Couturier, Lefebvre, Sprenger, Wirths, Zweckstetter, Bayer: "N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits." in: Acta neuropathologica, Vol. 126, Issue 2, pp. 189-205, 2013 (PubMed).