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  • 产品名称：GSK-484hydrochloride

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  • 产品厂商：Biovision
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简单介绍：
GSK-484hydrochloride
详情介绍：
Characteristics

PubChem CID: 86340151
Molecular Formula: C₂₇H₃₂ClN₅O₃
Cell Premeable: Yes

Salt form: No

GSK-484 is a potent and reversible inhibitor of PAD4 (Protein Arginine Deiminase 4) (IC₅₀ = 50 nM) that binds to the low-calcium form of the enzyme. It is selective for PAD4 over PAD1-3. GSK-484 blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human neutrophils.

Smiles: CN1C2=C(C=C(C=C2OC)C(=O)N3CCC(C(C3)N)O)N=C1C4=CC5=CC=CC=C5N4CC6CC6.Cl

InChi: InChI=1S/C27H31N5O3.ClH/c1-30-25-20(11-18(13-24(25)35-2)27(34)31-10-9-23(33)19(28)15-31)29-26(30)22-12-17-5-3-4-6-21(17)32(22)14-16-7-8-16,/h3-6,11-13,16,19,23,33H,7-10,14-15,28H2,1-2H3,1H/t19-,23+,/m0./s1

Inchi Key: MULKOGJHUZTANI-ADMBKAPUSA-N
Purity ≥ 98 %
Chemical Name ((3S,4R)-3-Amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride
Formula C₂₇H₃₂ClN₅O₃
Permeability Cell-permeable
Background Synonyms: ((3S,4R)-3-Amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride
Molecular Weight 510.03 g/mol
CAS-No 1652591-81-5
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 36 months