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  • 产品名称：Azamulin

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  • 产品厂商：Biovision
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简单介绍：
Azamulin
详情介绍：
Purpose A potent and specific inhibitor of CYP3A4
Characteristics Azamulin is a derivative of the antibiotic pleuromutilin. It is a highly selective inhibitor of the CYP3A family (IC50 = 0.03-0.24 μM as reported in Stresser et al., DMD, January 2004 vol. 32 no. 1 p105-112). Azamulin is a 15 and 13 fold more potent inhibitor of CYP3A4 compared to CYP3A5 or CYP3A7 respectively making it very useful for CYP3A4 activity assays and can be used as a benchmark in CYP3A4 inhibitor screening assays. It is at least 100 fold selective over other CYP isoforms (except CYP2J2 ~ 50-fold).
Purity ≥ 98 % by HPLC
Chemical Name (5-Amino-1H-1,2,4-triazol-3-yl)thio]acetic acid (3aS,4R,5S,6R,8R,9R,9aR,10R)-6-ethyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester,14-O-(5-(2-Amino1,3,4-triazolyl)thioacetyl)dihydromutilin, Antibiotic TDM 85-530
Formula C₂₄H₃₈N₄O₄S
Permeability Cell-permeable
Solubility DMSO (~10 mg/ml), Acetonitrile (~4.8 mg/ml)
Molecular Weight 478.65 g/mol
CAS-No 76530-44-4
Restrictions For Research Use only
Format Powder
Handling Advice Protect from air, light and moisture
Storage -20 °C
Expiry Date 24 months