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  • 产品名称：GKT-137831

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  • 产品厂商：Biovision
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GKT-137831
详情介绍：
Characteristics

PubChem CID: 58496428
Molecular Formula: C21H20ClN4O2
Cell Premeable: Yes

GKT-137831 is a novel pyrazolopyridinedione derivative that acts as a Nox4 and Nox1 inhibitor ((Ki 100-150 nM). GKT-137831 attenuates hypoxia-induced pulmonary vascular cell proliferation. Also a potent inhibitor of fibrosis and hepatocyte apoptosis.

Smiles: CN1C(=O)C=C2C(=C1C3=CC(=CC=C3)N(C)C)C(=O)N(N2)C4=CC=CC=C4Cl

InChi: InChI=1S/C21H19ClN4O2/c1-24(2)14-8-6-7-13(11-14)20-19-16(12-18(27)25(20)3)23-26(21(19)28)17-10-5-4-9-15(17)22/h4-12,23H,1-3H3

Inchi Key: RGYQPQARIQKJKH-UHFFFAOYSA-N
Purity ≥ 98 % by HPLC
Chemical Name 2-​(2-​chlorophenyl)-​4-​[3-​(dimethylamino)phenyl]-​5-​methyl-​1H-​pyrazolo[4,​3-​c]pyridine-​3,​6(2H,​5H)-​dione
Formula C21H20ClN4O2
Permeability Cell-permeable
Background Synonyms: 2-​(2-​chlorophenyl)-​4-​[3-​(dimethylamino)phenyl]-​5-​methyl-​1H-​pyrazolo[4,​3-​c]pyridine-​3,​6(2H,​5H)-​dione
Molecular Weight 394.85 g/mol
CAS-No 1218942-37-0
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months