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  • 产品名称：STIMA-1

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  • 产品厂商：Biovision
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简单介绍：
STIMA-1
详情介绍：
Characteristics

PubChem CID: 3801471
Molecular Formula: C₁₀H₈N₂O
Cell Premeable: Yes

Salt form: No

STIMA-1 (SH group-targeting compound that induces massive apoptosis) reactivates mutant p53. STIMA-1 can stimulate mutant p53 DNA binding in vitro and induce expression of p53 target proteins and trigger apoptosis in mutant p53-expressing human tumor cells. STIMA-1 is shown to covalently modify free thiols on mutant p53 in H1299-His175 cells and fully restore its DNA binding activity to the level seen with wild-type p53, resulting in upregulation of p53-dependent gene expression, including p21, PUMA, and Bax.

Smiles: C=CC1=NC(=O)C2=CC=CC=C2N1

InChi: InChI=1S/C10H8N2O/c1-2-9-11-8-6-4-3-5-7(8)10(13)12-9/h2-6H,1H2,(H,11,12,13)

Inchi Key: VCHFWHQHIKFOIC-UHFFFAOYSA-N
Purity ≥ 97 %
Chemical Name 2-Vinyl-4H-quinazolinol; SH group-targeting compound that induces massive apoptosis
Formula C₁₀H₈N₂O
Permeability Cell-permeable
Background Synonyms: 2-Vinyl-4H-quinazolinol
SH group-targeting compound that induces massive apoptosis
Molecular Weight 172.19 g/mol
CAS-No 91634-12-7
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months