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Characteristics
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Cell-permeable. A marine sponge metabolite that acts as a cytoplasmic microtubule inhibitor. Induces a complete and reversible breakdown/disruption of Golgi membranes into smaller vesicular structures and blocks the association of the ADP-ribosylation factor and beta-COP to the Golgi membrane. Ilimaquinone displays anticancer activity via GADD153-mediated pathway.
Synonyms: 3-[(Decahydro-1alpha,2beta,4abeta-trimethyl-5-methylene-1-naphthyl)methyl]-2-hydroxy-5-methoxybenzoquinone, IQ
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