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Characteristics
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A small molecule that restores tumor suppressor function to mutant p53 proteins. PRIMA-1 acts as an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations.
Synonyms: 2,2-bis(hydroxymethyl)-3-quinuclidinone
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