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Purpose
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A highly potent and selective inhibitor of the type 5 17-beta-hydroxysteroid dehydrogenase AKR1C3
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Characteristics
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A highly potent and selective inhibitor of the type 5 17-beta-hydroxysteroid dehydrogenase AKR1C3 (IC50= 94 nM). Displays much weaker inhibitory activity against AKR1C1, AKR1C2 and AKR1C4 (IC50> 30 µM).
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Purity
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≥ 98 % by HPLC
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Chemical Name
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1-(4-((2-Methylpiperidin-1-yl)sulfonyl)phenyl)pyrrolidin-2-one
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Formula
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C₁₆H₂₂N₂O₃S
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Permeability
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Cell-permeable
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Solubility
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DMSO
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