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  • 产品名称：JNJ-26854165

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  • 产品厂商：Biovision
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简单介绍：
JNJ-26854165
详情介绍：
Purpose A novel p53-activating tryptamine derivative that acts as a HDM2 (Human Double Minute-2) antagonist with potential antineoplastic activity.
Characteristics Off-white solid
Molecular formular: C21H20N4
Purity ≥ 98 % by HPLC
Chemical Name 1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine; Serdemetan
Formula C₂₁H₂₀N₄
Permeability Cell-permeable
Molecular Weight 328.41 g/mol
CAS-No 881202-45-5
Comment

Synonyms:
1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine, Serdemetan
A novel p53-activating tryptamine derivative that acts as a HDM2 (Human Double Minute-2) antagonist with potential antineoplastic activity. JNJ-26854165 inhibits the binding of the HDM2-p53 complex to the proteasome, blocking the degradation of p53. It displays potent anti-proliferative and apoptosis-inducing activity in a broad range of p53 wild type and mutant tumor models
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
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