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  • 产品名称：JAKInhibitor,Pyridone6

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  • 产品厂商：Biovision
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简单介绍：
JAKInhibitor,Pyridone6
详情介绍：
Purpose A potent JAK inhibitor
Characteristics  JAK Inhibitor, Pyridone 6 is a potent, reversible, ATP-competitive JAK inhibitor. It inhibits JAK1, 2, and 3 with IC₅₀ values of 15, 1, and 5 nM, respectively. Displays significantly weaker affinities (IC₅₀s = 130 nM - > 10 μM) for other protein tyrosine kinases. It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC₅₀ values of 50-100 nM.
Purity ≥ 97 % by HPLC
Chemical Name 2-​(1,​1-​Dimethylethyl)-​9-​fluoro-​1,​6-​dihydro-​7H-​benz[h]imidazo[4,​5-​f]isoquinolin-​7-​one; Pyridone 6; CMP 6
Formula C₁₈H₁₆FN₃O
Permeability Cell-permeable
Solubility DMSO (5 mg/mL)
Molecular Weight 309.3 g/mol
CAS-No 457081-03-7
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
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