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  • 产品名称：SIRT1Inhibitor,EX-527

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  • 产品厂商：Biovision
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简单介绍：
SIRT1Inhibitor,EX-527
详情介绍：
Purpose A SIRT1 inhibitor
Characteristics A potent SIRT1 inhibitor (IC50 = 38 nM). EX-527 is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100 µM. Enhances p53 acetylation in response to DNA damaging agents.
Purity ≥ 97 % by HPLC
Chemical Name EX-527, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Formula C₁₃H₁₃ClN₂O
Permeability Cell-permeable
Solubility DMSO (20 mg/ml)
Molecular Weight 248.71 g/mol
CAS-No 49843-98-3
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage 4 °C
Expiry Date 24 months
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