|
Comment
|
Synonyms:
4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 5-isoquinolinesulfonic acidCell-permeable.
KN-62 is a selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII, IC= 900 nM). It binds directly to the calmodulin of the enzyme. It does not affect the activity of several other kinases when tested at 10 µM. KN-62 also acts as a non-competitive antagonist of the purinergic receptor P2RX7 (IC = 15 nM)
|
