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Purpose
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A sub-nanomolar potent mTOR inhibitor
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Characteristics
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A potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC₅₀ = 0.45 nM nM). Displays 1469-fold selectivity over PI3Kα (IC₅₀ = 661 nM).
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Purity
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≥ 98 % by HPLC
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Chemical Name
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4-{6-[4-(3-Cyclopropyl-ureido)-phenyl]-4-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl}-piperidine-1-carboxylic acid methyl ester
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Formula
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C₂₆H₃₂N₈O₄
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Permeability
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Cell-permeable
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Solubility
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DMSO (> 10 mg/mL)
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