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Purpose
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A selective, picomolar-potent mTOR inhibitor
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Characteristics
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A potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC₅₀ = 0.08 nM). Displays 75-fold selectivity over PI3Kα (IC₅₀ = 6 nM).
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Purity
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≥ 98 % by HPLC
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Chemical Name
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4-(6-{4-[3-(4-Hydroxymethyl-phenyl)-ureido]-phenyl}-4-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid methyl ester
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Formula
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C₃₀H₃₄N₈O₅
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Permeability
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Cell-permeable
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Solubility
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DMSO (> 60 mg/mL)
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