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Purpose
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A TGF-β type I receptor (ALK5) inhibitor
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Characteristics
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A TGF-beta type I receptor (ALK5) inhibitor. Inhibits ALK5 autophosphorylation (IC50 = 4 nM). Can replace one of the four reprogramming factors Sox-2. RepSox has been successfully used in the direct reprogramming of mouse fibroblasts through induction of Nanog transcription.
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Purity
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≥ 98 % by HPLC
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Chemical Name
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2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine; E-616452
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Formula
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C₁₇H₁₃N₅
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Permeability
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Cell-permeable
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Solubility
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DMSO (>20 mg/ml)
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