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Purpose
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A potent, irreversible human leukocyte elastase (HLE) inhibitor
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Sequence
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Yes
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Characteristics
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A potent, irreversible inhibitor of human neutrophil elastase (HNE). The structure of the enzyme-inhibitor complex reveals crosslinking of the catalytic residues His-57 and Ser-195 by the peptidyl chloromethylketone.
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Purity
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≥ 98 % by TLC
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Chemical Name
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MeOSuc-Ala-Ala-Pro-Ala-chloromethylketone; MeOSuc-AAPA-CMK
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Formula
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C₂₀H₃₁ClN₄O₇
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Permeability
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Not-permeable
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Solubility
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DMSO
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