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  • 产品名称：PS48

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  • 产品厂商：Biovision
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PS48
详情介绍：
Characteristics An allosteric phosphoinositide-dependent protein kinase-1 (PDK1) activator (kDa= 10.3 µM). Binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP . It has recently been found that a combination of PS48, sodium butyrate, a histone deacetylase inhibitor and the gene Oct-4, could enhance the reprogramming efficiency of keratinocytes isolated from human skin or hair follicles over 25-fold.
Purity ≥ 95 % by HPLC
Chemical Name (2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoic acid
Formula C₁₇H₁₅ClO₂
Permeability Cell-permeable
Molecular Weight 286.75 g/mol
CAS-No 1180678-32-7
Research Area Kinases/Phosphatases
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
Supplier Images
image for PS48 (ABIN629222) PS48
Product cited in: Aflaki, Stubblefield, Maniwang, Lopez, Moaven, Goldin, Marugan, Patnaik, Dutra, Southall, Zheng, Tayebi, Sidransky: "Macrophage models of Gaucher disease for evaluating disease pathogenesis and candidate drugs." in: Science translational medicine, Vol. 6, Issue 240, pp. 240ra73, 2014 (PubMed).