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  • 产品名称：(R,S)-Lenalidomide

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  • 产品厂商：Biovision
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简单介绍：
(R,S)-Lenalidomide
详情介绍：
Characteristics Cell-permeable. An analog of thalidomide that was originally found based on its ability to effectively inhibit tumor necrosis factor production. Lenalidomide is 50,000 times more potent than thalidomide in inhibiting Tumor Necrosis Factor-alpha (TNF-alpha). Displays potent anti-tumor and anti-inflammatory effects as well as modulates and potentiates host immune responses against multiple myeloma.
Purity ≥ 98 % by HPLC
Chemical Name (R,S)-3-(4-amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione
Formula C₁₃H₁₃N₃O₃
Permeability Cell-permeable
Molecular Weight 259.26 g/mol
CAS-No 191732-72-6
Research Area Kinases/Phosphatases
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
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Product cited in: Fionda, Malgarini, Soriani, Zingoni, Cecere, Iannitto, Ricciardi, Federico, Petrucci, Santoni, Cippitelli: "Inhibition of glycogen synthase kinase-3 increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of STAT3." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 12, pp. 6662-72, 2013 (PubMed).