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  • 产品名称：CD82(human):293TLysate

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  • 产品厂商：BioLeaf
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CD82(human):293TLysate
详情介绍：
Characteristics CD82 (KAI1) is a highly glycosylated membrane protein belonging to the tetraspanins. The tetraspanins are a family of proteins that possesses four transmembrane domains, namely, the NH2- and COOH-terminal cytoplasmic domains, and two extracellular loops. A few tetraspanins, including CD151, tetraspanin 8, CD82, and CD9, are involved in tumor metastasis. CD82 is a metastasis suppressor implicated in cell fusion, adhesion, migration, apoptosis, and cell morphology alterations. It has attracted much attention in various human cancers, such as prostate, pancreatic, lung, gastric, hepatic, and colorectal cancers. As a membrane protein, CD82 interacts with integrins, other tetraspanins (CD9, CD63, and CD81), cell-surface molecules (CD4, CD8, CD19, and CD21), and MHC class I and class II, which includes CD82 into a newly defined tetraspanin web Two types of PTMs, namely, glycosylation and palmitoylation, occur on CD82. The palmitoylation is reportedly an important PTM for its motility- and invasiveness-inhibitory activity. On the other hand, CD82 has three potential N-glycosylation sites located at the large extracellular loop. CD82N- glycosylation has been previously shown to play a potent role in cell adhesion and motility. White et al. found that CD82 has distinct heterogeneous protein band patterns in various human cancer cell lines, which are most likely associated with N-glycosylation. Lysate of human CD82 transfected 293T cells
Alternative Name CD82
Research Area Cancer, Transcription Factors, CD Antigens, Adaptive Immunity, Surface Receptors of Immune Cells
Application Notes CD82 (h): 293T Lysate is suitable as a Western Blotting positive control for human reactive CD82 antibodies. Recommended use: 10-20 µl per lane. Control 293T Lysate: 293LYS is available as a Western Blotting negative control lysate derived from non-transfected 293T cells.
Restrictions For Research Use only
Handling Advice Repeated freezing and thawing should be minimized. Sample vial should be boiled once prior to use. Non-hazardous. No MSDS required.
Storage -20 °C
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Product cited in: Park, Tait, Kawasaki, Rowley, Mackay: "Closer association of IA-2 humoral autoreactivity with HLA DR3/4 than DQB1*0201/*0302 in Korean T1D patients." in: Annals of the New York Academy of Sciences, Vol. 1037, pp. 104-9, 2005 (PubMed).

Iwama, Ikezaki, Kikuoka, Kim, Matsuoka, Yanagawa, Sato, Hoshi, Sakamaki, Sugihara: "Association of HLA-DR, -DQ genotype and CTLA-4 gene polymorphism with Graves' disease in Japanese children." in: Hormone research, Vol. 63, Issue 2, pp. 55-60, 2005 (PubMed).

Spriewald, Witzke, Wassmuth, Wenzel, Arnold, Philipp, Kalden: "Distinct tumour necrosis factor alpha, interferon gamma, interleukin 10, and cytotoxic T cell antigen 4 gene polymorphisms in disease occurrence and end stage renal disease in Wegener's granulomatosis." in: Annals of the rheumatic diseases, Vol. 64, Issue 3, pp. 457-61, 2005 (PubMed).

Quintero, Pizarro, Rodrigo, Piqué, Lanas, Ponce, Miño, Gisbert, Jurado, Herrero, Jiménez, Torrado, Ponte, Díaz-de-Rojas, Salido: "Association of Helicobacter pylori-related distal gastric cancer with the HLA class II gene DQB10602 and cagA strains in a southern European population." in: Helicobacter, Vol. 10, Issue 1, pp. 12-21, 2005 (PubMed).

Voorter, de Groot, Meertens, Bontrop, van den Berg-Loonen: "Allelic polymorphism in introns 1 and 2 of the HLA-DQA1 gene." in: Tissue antigens, Vol. 65, Issue 1, pp. 56-66, 2005 (PubMed).

Arnold, Pei, Spriewald, Wassmuth: "Anti-HLA class II antibodies in kidney retransplant patients." in: Tissue antigens, Vol. 65, Issue 4, pp. 370-8, 2005 (PubMed).