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Background
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This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA . The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 13.
Alias Symbols: ASF, SF2, SFRS1, SF2p33, SRp30a, MGC5228, FLJ53078
Protein Interaction Partner: TRAF3IP2, HUWE1, SPRTN, STAU1, UBC, MDM2, ZBTB1, RNF2, EZH2, EED, SUZ12, PARK2, SRPK2, SRPK1, SRPK3, FBXO6, YWHAE, U2AF2, PAN2, MPG, CIR1, FN1, CDK6, HNRNPA0, RNPS1, SRSF10, NXF1, PRPF4, BCL10, U2AF1, SRSF4, MAGOH, SMURF1, EIF4A3, ESR1, ECT2, BRCA1, BARD1
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