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Background
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Phosphatidylcholine (PC)-specific phospholipases D (PLDs, EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.
Alias Symbols: PLD2
Protein Interaction Partner: UBC, RPS6KB1, CUL3, AQP3, RPTOR, PEA15, PIP5K1A, STXBP1, DPYSL2, BIN1, MTOR, CAV1, AMPH, OPRM1, ALDOC, GM2A, PRKCD, PRKCA, PLCG1, LCK, GAPDH, FYN, EGFR, CSK, ALDOA, ARF1, ACTB, ACTN1, CAV2, SRC,
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