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Background
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The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.
Alias Symbols: C-C, CD128, CD181, CKR-1, IL8R1, IL8RA, CMKAR1, IL8RBA, CDw128a, C-C-CKR-1
Protein Interaction Partner: UBE2C, PDCD6IP, TUBA1A, CDK1, CXCL5, PPBP, GNA14, CXCL1, CXCL8, CXCR1, CXCR2, GNAI2, GNA15, CXCL3, CXCL2, CXCL6, ADRA1A,
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