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Background
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The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.
Alias Symbols: NAF, GCP1, LECT, LUCT, NAP1, CXCL8, GCP-1, LYNAP, MDNCF, MONAP, NAP-1
Protein Interaction Partner: RELA, IL5, POMGNT1, ARFGAP3, BAG6, SGTA, EP300, tat, WASF1, SDC1, CCL4, PF4, IL12A, CXCL8, CXCR1, CXCR2, GNAI2, MMP9, CTSL, ACKR1, CSNK2A1, CCL5, HIST3H3, HDAC3, NCOR2, POLR2A, IKBKB, CHUK, NFKB1,
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