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Background
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This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
Alias Symbols: APLP
Protein Interaction Partner: ZNF24, GLP1R, ING5, RBM48, LRIF1, UTP14A, SETDB1, HAP1, GDF9, EEF1A1, ARRB1, KAT5, TSC22D1, VIM, TK1, SNCA, SMN1, RAP1B, PIN1, CSNK2B, RCC1, CDKN1A, CDK4, ANXA7, TOE1, CRCT1, MPHOSPH6, PHF10, PCDHA4, HLA-DQA1, EIF2S2, DAB1, CDKN2C, TCF21, STX5, APBB1, NAC
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