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Background
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HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. TARDBP is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription.HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: HNRPA0
Protein Interaction Partner: UBC, SUMO2, SUMO3, STAU1, RPA3, RPA2, RPA1, EED, RNF2, DYNC1LI1, PSMD13, PSMD12, PSMD8, MAP2, DYNC1I2, DHX9, ABCF1, RPS27, TARDBP, CSF2, NPM1, LMNA, AICDA, MAPKAPK2, GADD45A, U2AF2, VCAM1, SRSF1, NKX3-1, MTNR1A, ITGA4, IL7R, HNRNPK, HNRNPH3, HNRNPH2, HNRN
Protein Size: 305
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