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  • 产品名称：TumorNecrosisFactor(Ligand)Superfamily,Member4(TNFSF4)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
TumorNecrosisFactor(Ligand)Superfamily,Member4(TNFSF4)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the N-terminus, and has a calculated MW of 16.9 kDa. The predicted N-terminus is His. The reducing (R) protein migrates as 25-30 kDa in SDS-PAGE due to glycosylation.
Purity >90 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Grade HPLC verified
Background Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46 % amino acid sequence identity with its mouse counterpart.
Molecular Weight 16.9 kDa
NCBI Accession NP_003317
UniProt P23510
Pathways Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4) (Active) protein (His tag) (ABIN2870675) Human OX40 Ligand, His Tag (HPLC-verified) on SDS-PAGE under reducing (R) condition. ...
Binding Studies (Bind) image for Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4) (Active) protein (His tag) (ABIN2870675) Immobilized Human OX40 Ligand, His Tag (Cat# OXL-H52Q8) at 5 μg/mL (100 μl/well) can ...