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  • 产品名称：LeptinReceptor(LEPR)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
LeptinReceptor(LEPR)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 121 kDa. The protein migrates as 150-165 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Measured by its ability to inhibit Leptin-dependent proliferation of BaF3 mouse pro-B cells transfected with rhLEPR-Fc. The ED50 for this effect is typically 0. 015. 13 μg/ml in the presence of 3 ng/mL rhLeptin.
Background Leptin receptor (LEPR) is also known as LEP-R, cluster of differentiation 295 (CD295), OB-R and B219, is a single-transmembrane-domain receptor of the gp130 family of cytokine receptors. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this protein have been associated with obesity and pituitary dysfunction. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.
Molecular Weight 121 kDa
NCBI Accession NP_002294
UniProt P48357
Pathways JAK-STAT Signaling, AMPK Signaling, Feeding Behaviour
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
Supplier Images
SDS-PAGE (SDS) image for Leptin Receptor (LEPR) (Active) protein (Fc Tag) (ABIN2181459) Human Leptin R, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained ...
Background publications Tutino, Notarnicola, Guerra, Lorusso, Caruso: "Increased soluble leptin receptor levels are associated with advanced tumor stage in colorectal cancer patients." in: Anticancer research, Vol. 31, Issue 10, pp. 3381-3, 2011 (PubMed).

Tutino, Notarnicola, Guerra, Lorusso, Caruso: "Increased soluble leptin receptor levels are associated with advanced tumor stage in colorectal cancer patients." in: Anticancer research, Vol. 31, Issue 10, pp. 3381-3, 2011 (PubMed).

Sharma, McCue, Dunn: "Diabetic kidney disease in the db/db mouse." in: American journal of physiology. Renal physiology, Vol. 284, Issue 6, pp. F1138-44, 2003 (PubMed).

Sharma, McCue, Dunn: "Diabetic kidney disease in the db/db mouse." in: American journal of physiology. Renal physiology, Vol. 284, Issue 6, pp. F1138-44, 2003 (PubMed).