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  • 产品名称：delta-Like1(DLL1)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
delta-Like1(DLL1)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 58.4 kDa. The protein migrates as 66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Delta-like protein 1 (DLL1) is also known as Drosophila Delta homolog 1 (Delta1 or H-Delta-1), which contains one DSL domain and eight EGF-like domains. DLL1 is ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. As for expression, DLL1 is expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. Furthermore, DLL1 acts as a ligand for Notch receptors. Also, DLL1 can block the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.
Molecular Weight 58.4 kDa
NCBI Accession NP_005609
UniProt O00548
Research Area Embryogenesis, Embryonic stem cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Transcription Factors, Neurogenesis, Lineage Markers
Pathways Notch Signaling, Stem Cell Maintenance
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 150 mM NaCl, pH 7.5
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for delta-Like 1 (DLL1) (Active) protein (His tag) (ABIN2870633) Human DLL1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ove...