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  • 产品名称：PSME3(PSME3)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
PSME3(PSME3)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 30.3 kDa. The protein migrates as 28-33 kDa under reducing (R) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Proteasome activator complex subunit 3 (PSME3),a member of the PA28 family, is also known as 11S regulator complex subunit gamma (REG-gamma), activator of multicatalytic protease subunit 3 and proteasome activator 28 subunit gamma (PA28gamma). PSME3 activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. PSME3 can also facilitate the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. Furthermore,PSME3 may also be involved in cell cycle regulation.
Molecular Weight 30.3 kDa
NCBI Accession NP_00578
UniProt P61289
Research Area Immunology, Proteolysis / Ubiquitin, Proteasome
Pathways Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Hepatitis C, Synthesis of DNA
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 200 mM NaCl, pH 8.0
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for PSME3 (PSME3) (Active) protein (His tag) (ABIN2870689) Human PSME3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...