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  • 产品名称：V-SetDomainContainingTCellActivationInhibitor1(VTCN1)(Active)protein(Biotin,His

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  • 产品厂商：ACROBiosystems
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简单介绍：
V-SetDomainContainingTCellActivationInhibitor1(VTCN1)(Active)protein(Biotin,Histag)
详情介绍：
Brand MABSol®,UltraLys
Specificity The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with biotins using standard chemical labeling method. A standard biotin reagent (13.5 angstroms) is used in this product.
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.1 kDa. The protein migrates as 43-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Grade Ultra Sensitive
Background V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.
Molecular Weight 26.1 kDa
NCBI Accession NP_078902
UniProt Q7Z7D3
Comment

A chemically labeled biotinylated protein with ultra sensitivity.
The product is produced using a chemical labeling approach. The primary amines in the side chains of lysine residues and the N-terminus of protein are conjugated with biotins.
Chemical labeling usually results in multiple biotin attachment on a single protein molecule, which could potentially lead to higher detection sensitivity.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (Active) protein (Biotin,His tag) (ABIN2870528) Biotinylated Human B7-H4 on SDS-PAGE under reducing (R) condition. The gel was staine...
Binding Studies (Bind) image for V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (Active) protein (Biotin,His tag) (ABIN2870528) Immobilized anti-B7-H4 mAb (Human IgG1) at 2 μg/mL can bind Biotinylated Human B7-H4 ...