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  • 产品名称：TCellImmunoreceptorwithIgandITIMDomains(TIGIT)(AA26-143)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
TCellImmunoreceptorwithIgandITIMDomains(TIGIT)(AA26-143)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.8 kDa. The protein migrates as 20-25 kDa under reducing (R) condition (SDS-PAGE).
Purity >90 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Molecular Weight 14.8 kDa
NCBI Accession NP_001139797
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 26-143) (Active) protein (His tag) (ABIN4949191) Mouse TIGIT, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...