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  • 产品名称：TCellImmunoreceptorwithIgandITIMDomains(TIGIT)(AA22-141)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
TCellImmunoreceptorwithIgandITIMDomains(TIGIT)(AA22-141)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.1 kDa. The protein migrates as 42-50 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 0.1 EU per μg by the LAL method.
Background TIGIT (also called T cell immunoreceptor with Ig and ITIM domains) is one newly discovered immune receptor on some percentage of T cells and Natural Killer Cells(NK). It is also identified as WUCAM and Vstm3. TIGIT could bind to CD155(PVR) on dendritic cells(DCs), macrophages, etc. with high affinity, and also to CD112(PVRL2) with lower affinity. TIGIT expressing CD8+ T cells has been shown to be expanded and associated with clinical markers of HIV disease progression in a diverse group of HIV infected individuals. TIGIT and PD-1 has been shown to be over expressed on tumor antigen-sepcific (TA-specific) CD8+ T cells and CD8+ tumor infiltrating lymphocytes (TILs) from individuals with melanoma. Blockade of TIGIT and PD-1 led to increased cell proliferation, cytokine production, and degranulation of TA-specific CD8+ T cells and TIL CD8+ T cells.
Molecular Weight 40.1 kDa
UniProt Q495A1
Restrictions For Research Use only
Format Lyophilized
Reconstitution For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM tris, 100 mM glycine, pH 7.5
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) (Active) protein (Fc Tag) (ABIN4949144) Human TIGIT, mouse IgG2a Fc tag on SDS-PAGE under reducing (R) condition. The gel was...
image for T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) (Active) protein (Fc Tag) (ABIN4949144) Measured by its binding ability in a functional ELISA. Immobilized Human CD155, Fc Ta...