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  • 产品名称：Insulin-LikeGrowthFactorBindingProtein4(IGFBP4)(AA22-258)(Active)protein(Histag

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  • 产品厂商：ACROBiosystems
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简单介绍：
Insulin-LikeGrowthFactorBindingProtein4(IGFBP4)(AA22-258)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.9 kDa. The protein migrates as 33-37 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Insulin-like growth factor-binding protein 4 (IGFBP-4) is also known as IGF-binding protein 4, which contains an IGFBP domain and a thyroglobulin type-I domain. IGFBP-4 binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. IGFBP-4 is secreted by all colon cancer cells.
Molecular Weight 27.9 kDa
NCBI Accession NP_001543
Pathways WNT Signaling, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) (AA 22-258) (Active) protein (His tag) (ABIN4949113) Human IGFBP-4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ...
Binding Studies (Bind) image for Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) (AA 22-258) (Active) protein (His tag) (ABIN4949113) Immobilized Human IGFBP-4, His Tag (Cat# IG4-H52E4) at 2 μg/mL (100 µl/well),can bind...