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  • 产品名称：PoliovirusReceptor-Related2(HerpesvirusEntryMediatorB)(PVRL2)(AA32-360)(Active)

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  • 产品厂商：ACROBiosystems
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简单介绍：
PoliovirusReceptor-Related2(HerpesvirusEntryMediatorB)(PVRL2)(AA32-360)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 62.2 kDa. The protein migrates as 70-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).
Molecular Weight 62.2 kDa
NCBI Accession NP_002847
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 32-360) (Active) protein (Fc Tag) (ABIN4949134) Human Nectin-2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained ...
Binding Studies (Bind) image for Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 32-360) (Active) protein (Fc Tag) (ABIN4949134) Immobilized Human CD112, Fc Tag (Cat# PV2-H5253) at 10 μg/mL (100 μL/well) can bind B...