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  • 产品名称：CiliaryNeurotrophicFactorReceptor(CNTFR)(AA23-346)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
CiliaryNeurotrophicFactorReceptor(CNTFR)(AA23-346)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 36.9 kDa. The protein migrates as 45-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized human CTNFR at 10 μg/mL ( 100 μL/well ) can bind biotinylated human CNTF with a linear ranger of 3.2 - 100 ng/mL.
Background Ciliary neurotrophic factor receptor subunit alpha (CNTFR or CNTFR-alpha) belongs to the type I cytokine receptor family and type 3 subfamily. CNTFR contains two fibronectin type-III domains and one Ig-like C2-type (immunoglobulin-like) domain. This receptor and its cognate ligand support the survival of neurons. This receptor is most closely related to the interleukin-6 receptor. This receptor possesses an unusual attachment to the cell membrane through a glycophosphatidylinositol linkage.
Molecular Weight 36.9 kDa
UniProt P26992
Pathways JAK-STAT Signaling, Feeding Behaviour
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Ciliary Neurotrophic Factor Receptor (CNTFR) (AA 23-346) (Active) protein (His tag) (ABIN2180891) Human CNTF R alpha, His Tag on SDS-PAGE under reducing (R) condition. The gel was sta...