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  • 产品名称：TumorNecrosisFactor(Ligand)Superfamily,Member18(TNFSF18)(AA50-177)(Active)prote

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  • 产品厂商：ACROBiosystems
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简单介绍：
TumorNecrosisFactor(Ligand)Superfamily,Member18(TNFSF18)(AA50-177)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 46.2 kDa. As a result of glycosylation, the protein migrates as 46 kDa under reducing (R) condition, and 90 kDa under non-reducing (NR) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.
Molecular Weight 46.2 kDa
UniProt Q9UNG2
Research Area Growth Factors
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18) (AA 50-177) (Active) protein (Fc Tag) (ABIN2181165) Human GITR Ligand, Fc Tag on SDS-PAGE under reducing (R) and no-reducing (NR) conditi...
Binding Studies (Bind) image for Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18) (AA 50-177) (Active) protein (Fc Tag) (ABIN2181165) Immobilized Human GITR, His Tag (Cat# GIR-H5228) at 2 μg/mL (100 μl/well) can bind Hu...