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  • 产品名称：FcFragmentofIgG,Receptor,Transporter,alpha(FCGRT)(AA16-289)(Active)protein(Stre

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  • 产品厂商：ACROBiosystems
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简单介绍：
FcFragmentofIgG,Receptor,Transporter,alpha(FCGRT)(AA16-289)(Active)protein(StrepTag,Histag)
详情介绍：
Characteristics Porcine FcRn / FCGRT & B2M heterodimer protein, produced by co-expression of FCGRT and B2M, has a calculated MW of 32.3 kDa (FCGRT) and 12.8 kDa (B2M). Subunit FCGRT is fused with a polyhistidine tag at the C-terminus and subunit Beta-2 microglobulin (B2M) is fused with a Strep II tag at the C-terminus. The predicted N-terminus is Asp 16 (FCGRT) & Val 21 (B2M). The reducing (R) protein migrates as 36 kDa (FCGRT) and 15 kDa (B2M) respectively.
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
Molecular Weight 32.3 kDa (FCGRT), 12.8 kDa (B2M)
Gene ID 18, 17
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for Fc Fragment of IgG, Receptor, Transporter, alpha (FCGRT) (AA 16-289) (Active) protein (Strep Tag,His tag) (ABIN4949195) Porcine FcRn / FCGRT & B2M on SDS-PAGE under reducing (R) condition. The gel was stai...