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  • 产品名称：Gremlin1(GREM1)(AA25-184)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Gremlin1(GREM1)(AA25-184)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 44.2 kDa. The protein migrates as 48-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.
Molecular Weight 44.2 kDa
NCBI Accession NP_037504
UniProt O60565
Pathways Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 150 mM NaCl, pH 7.5 with 1 mM EDTA
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for Gremlin 1 (GREM1) (AA 25-184) (Active) protein (Fc Tag) (ABIN4949105) Human Gremlin / GREM1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was s...
Binding Studies (Bind) image for Gremlin 1 (GREM1) (AA 25-184) (Active) protein (Fc Tag) (ABIN4949105) Immobilized Human BMP-2, Tag Free with a linear range of 0.0008-0.08 μg/mL.