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  • 产品名称：ActivinAReceptor,TypeIIA(ACVR2A)(AA20-134)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
ActivinAReceptor,TypeIIA(ACVR2A)(AA20-134)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40 kDa. The protein migrates as 30-33 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Activin receptor type-2A (ACVR2A) is also known as Activin receptor type IIA, ACTR-IIA, ACTRIIA and ACVR2,which is single-pass type I membrane protein. ACVR2A belongs to the protein kinase superfamily,TKL Ser/Thr protein kinase family and TGFB receptor subfamily.On ligand binding,ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.ACVR2A is Receptor for activin A, activin B and inhibin A as well. Several type I I activin receptors have been identified and bind to different activins with different affinities.
Molecular Weight 40 kDa
NCBI Accession NP_001607
UniProt P27037
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Activin A Receptor, Type IIA (ACVR2A) (AA 20-134) (Active) protein (Fc Tag) (ABIN2180558) Human Activin RIIA, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stai...
Binding Studies (Bind) image for Activin A Receptor, Type IIA (ACVR2A) (AA 20-134) (Active) protein (Fc Tag) (ABIN2180558) Immobilized Human Activin A, Tag Free with a linear range of 0.08-0.625 μg/mL.