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  • 产品名称：Insulin-LikeGrowthFactorBindingProtein3(IGFBP3)(AA28-291)(Active)protein(Histag

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  • 产品厂商：ACROBiosystems
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简单介绍：
Insulin-LikeGrowthFactorBindingProtein3(IGFBP3)(AA28-291)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 31 kDa. The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Insulin-like growth factor-binding protein 3 is also known as IGFBP3, is a protein that, in humans, is encoded by the IGFBP3 gene. IGFBP3 forms a ternary complex of about 140 ~150 kDa with IGF1 or IGF2 and a glycoprotein insulin-like growth factor acid-labile subunit (ALS), thus alter the interaction of IGFs with their cell surface receptors. IGFBP3 exerts either proapoptotic or growth stimulatory effects depending upon the cellular context. Studies have shown that IGFBP3 can leads to the induction of apoptosis dependent or independent of the IGF-IGF receptor axis, accordingly acts as a negative regulator of tumorigenesis and progressing in certain carcinomas. The highest expression level is found in the nonparanchymal cells of the liver. Expression levels are also higher during extrauterine life and peak during puberty.
Molecular Weight 31 kDa
UniProt P17936
Research Area Diabetes, Metabolism, Growth Factors
Pathways Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) (AA 28-291) (Active) protein (His tag) (ABIN2181268) Human IGFBP-3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ...
Binding Studies (Bind) image for Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) (AA 28-291) (Active) protein (His tag) (ABIN2181268) Immobilized Human IGF-I, Fc Tag (Cat# IG1-H4269) at 5 μg/mL (100 µl/well),can bind Hu...
Binding Studies (Bind) image for Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) (AA 28-291) (Active) protein (His tag) (ABIN2181268) Immobilized Human IGFBP-3, His Tag (Cat# IG3-H5229) at 5 μg/mL (100 μl/well) can bind...