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  • 产品名称：FK506BindingProtein1A,12kDa(FKBP1A)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
FK506BindingProtein1A,12kDa(FKBP1A)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 12.8 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus).FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.
Molecular Weight 12.8 kDa
UniProt P62942
Research Area Immunology
Pathways Negative Regulation of Transporter Activity, Methionine Biosynthetic Process
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM HEPES, 150 mM NaCl, pH 7.5
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for FK506 Binding Protein 1A, 12kDa (FKBP1A) (Active) protein (His tag) (ABIN2870639) Human FKBP12, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained o...